Can't decide which one to buy.F-50 is around 250-300$ and the F-300 at 850.I have the money for the F-300,but I will 99% change the 'buckers and they both have tune-o-matic bridge which I want on my new guitar.So is there any other major difference between them worth the extra money?

I guess the woods are different but do they really matter since I'm gonna use it for grind with tons of distortion? (second important question for you)

Wood DOES make a difference. A very big one. I don't know anything about Agathis, but as they have it in a lower range guitar, I guess it's cheap and bad. But I don't know.

Stuff that's better with the F300:
-Probably better body wood
-Stiffer neck
-Cooler inlays
-Better pickups (well, depends on what you like, but...)
-Probably a 3way toggle instead of a 2way....

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get the f-300 man

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If your willing to spend $850 then look around, u might fnd a better guitar for cheaper.

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I, personally, would for $850 get a Jackson of some sort, either a KE3 (allready have one though) or an RR3 or RR5. But that's just me...

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i would do that too, but since he was looking at those two specific guitars i didnt tell him to

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heh, i knew someone would throw "you can get a better guitar for cheaper" in there somewhere.

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get the f-300, better wood, nicer pickups, and it has neck through construction instead of bolt on, so its got way better feel to it, i'm buying one soon.
i've played the f-50, its pretty good, but if you got one, you would definitly want to change the pickups, and it still doesnt feel as nice as the f-300.