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  #81  
Old 2006-07-06, 19:17
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L,B'XXX L,B'XXX is offline
dsnt trust ne1 < 30
 
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Just being neighborly. I know that crap. I worked with diseased people.
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My eldest son's bipolar website: www.bipolarmanifesto.com

-wally: Mom, you shouldn't play after me because it makes you sound even worse than you already do. -wally:*grumbles and whispers quietly* I guess it's cuz I love you or something, but you're still a TURD
Grimm:I could read your mind but its in font size .5
Amadeus:Oh, and was there a cesserole (never mind spelling) involved?
Paddy:the fact that you didn't end up on a kids show makes me question my atheism
Dyldo: You evil strumpet!
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  #82  
Old 2006-07-06, 19:21
PST 88 PST 88 is offline
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Everybody knows that crap (though that's a funny response to a post in which the only assertation is that your last few posts were nonsense and shouldn't have been written). I was just pointing out the various ways in which you weren't being neighborly, unless 'being neighborly' means 'making an irrelevant and useless comment over the internet to somebody you've never seen.' I'll admit to being out of touch if that's what 'being neighborly' now means.
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  #83  
Old 2006-07-06, 21:01
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L,B'XXX L,B'XXX is offline
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Well, get with the program. I guess you speak a different language in Chi-town than we do over here.
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My eldest son's bipolar website: www.bipolarmanifesto.com

-wally: Mom, you shouldn't play after me because it makes you sound even worse than you already do. -wally:*grumbles and whispers quietly* I guess it's cuz I love you or something, but you're still a TURD
Grimm:I could read your mind but its in font size .5
Amadeus:Oh, and was there a cesserole (never mind spelling) involved?
Paddy:the fact that you didn't end up on a kids show makes me question my atheism
Dyldo: You evil strumpet!
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  #84  
Old 2006-07-06, 23:10
PST 88 PST 88 is offline
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My neighbors here are mostly black and on welfare. Being neighborly with them means having a beer on the stoop, which is actually a kind of being neighborly I can get behind.

But I'm pretty sure that Chicago, as a big and important city, is superior to the rest of America, and therefore its denizens are superior to people living in, say, Ohio.
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  #85  
Old 2006-07-06, 23:23
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philkilla philkilla is offline
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or you could buy a fan for 5 dollars
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My Trust is in WHISKEY and WEEDand SLAYER
Long live DIMEBAG
ROGspace Cunts. Book us


Quote:
Originally Posted by far_beyond_sane
You thought of mixing wheat flour with saturated fat, and putting it the resultant shit in a styrofoam cup. Shine on, you crazy dead yellow diamond.

Quote:
Originally Posted by johnmansley
May the best cunt win.
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  #86  
Old 2006-07-06, 23:41
PST 88 PST 88 is offline
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$2, but it's not that simple. It's not a hardware problem. The software is fucked up, and though I've replaced it several times under the directions of HP professionals, it continues to die on me. I have to use ice packs to be able to use the computer for longer than a half hour at a time, but they melt pretty quickly.
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  #87  
Old 2006-07-07, 05:18
blizzard_beast blizzard_beast is offline
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Originally Posted by sqol
You're rubbish! I'll have to fly the flag for the UK on my own then


Hey! At least I got some credits...

0.42
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  #88  
Old 2006-08-30, 18:04
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Soulinsane Soulinsane is offline
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Well, we're ranked 381 now
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  #89  
Old 2006-10-31, 10:01
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far_beyond_sane far_beyond_sane is offline
You gamma-minus fucktards
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Quote:
Originally Posted by far_beyond_sane
What the hell?

I'm perfectly serious.

The nerdier elements amongst you will have heard of the seti@home project. They send data, radio waves, that they collect from the cosmos to your home computer, and your computer scans the data looking for patterns or messages that alien species beam off into the cosmos. It's pretty much a waste of time that is designed to keep beardy Trekkies off the streets. But it was the first example of people pooling their CPU power for a common cause. They did it with Mersenne prime numbers as well.

But fuck all that. This is much cooler.

The rosetta@home project is similar, yet much more useful. It is exactly the same structure of project (they create data, send it to your CPU, your CPU solves it and sends it back) but it does something more handy - determining the folding structure of a protein.

So who gives a shit about protein origami? Everyone in a white coat. Proteins, like all other natural systems, tend towards their natural equilibrium, their most stable state. Unfortunately that is very hard to determine because proteins are made out of many, many amino acids all of which fold up and behave differently. When you get a string of, say, 800 amino acids to make a protein, we have literally no fucking idea how the outside of the molecule looks unless we test them.

So, what does a large brute-force numerical solution to a problem need? Yes - masses and masses of computer power. Hence, this project. Here's the stuff they're working on:

"Malaria: We are part of a collaborative project headed by Austin Burt at Imperial College in London that is one of the Gates Foundation "Grand Challenge Projects in Global Health". Malaria is caused by a parasite that spends part of its life cycle inside the mosquito, and is passed along to humans by mosquito bites. The idea behind the project is to make mosquitoes resistant to the parasite by eliminating genes required in the mosquito for the parasite to live. Our part of the project is to use our computer based design methods (ROSETTA) to engineer new enzymes that will specifically target and inactivate these genes.

Anthrax: We are using ROSETTA to help John Collier's research group at Harvard build models of anthrax toxin that should contribute to the development of treatments. You can read the abstract of a paper describing some of this work at http://www.pnas.org/cgi/content/abstract/102/45/16409.

HIV: One of the reasons that HIV is such a deadly virus is that it has evolved to trick the immune system. We are collaborating with researchers in Seattle and at the NIH to try to develop a vaccine for HIV. Our role in this project is central--we are using ROSETTA to design small proteins that display the small number of critical regions of the HIV coat protein in a way that the immune system can easily recognize and generate antibodies to. Our goal is to create small stable protein vaccines that can be made very cheaply and shipped all over the world.

Other viruses: We have been collaborating with Pam Bjorkman's laboratory at Cal Tech to use the ROSETTA protein-protein docking methodology to build models of herpes simplex virus proteins in complex with human proteins.

Alzheimer's disease: Alzheimer's and many other diseases are likely to be caused by abberant protein folding in which proteins form large aggregated structures called amyloids rather than folding up into their normal biologically active states. A big advance was made recently by David Eisenberg's research group at UCLA in solving the first structure of an amyloid. We are collaborating with their research group to use the structure to predict which parts of proteins are likely to form amyloids, which will be a first step to blocking amyloid formation and hopefully disease.

Cancer: Cancer can be caused by mutations in key genes that disrupt normal cellular control processes. We are developing methods for cutting DNA at specific sites in the genome, and we will be targeting sites that are implicated in cancer. After these sites are cut, they should be repaired by the cell using a second, unmutated copy of the gene and the cell should no longer be cancerous. This is a very specific form of gene therapy that, if successful, will circumvent one the main objections to current gene therapy methods; namely, current methods insert the unmutated copy of a gene randomly into the genome, and if the insertion point happens to be near an oncogene, the gene therapy will cure one disease but cause another. Because our methods will target specific sites instead of random sites, they should avoid this pitfall.

Prostate Cancer: The androgen receptor (AR) binds testosterone and is responsible for normal male development. When the AR becomes hypersensitive to testosterone, prostate cancer is the result. The current treatment for prostate cancer, called "hormone therapy", involves lowering the amount of testosterone available (sometimes by castration). Many malignant tumors are resistant to this therapy, however, so we are applying our protein design methodology to find different ways to inhibit the AR and to treat prostate cancer. Specifically, we are trying to design proteins that will disable the AR even in the presence of testosterone. We are doing this by designing proteins that will prevent the AR from entering the nucleus of the cell (which is where it does its dirty work), and also preventing it from binding DNA and activating tumor-specific genes even if it does get into the nucleus."


If you're anything like me, you probably leave your computer on for several hours a day while you're not around it. So make it do something useful instead of display that Cephalic Carnage screensaver over and over again. This program does absolutely nothing but work on determining the structure of a protein while you're away from your PC.

And trust me, if your computer figures out a dramatically effective way that antibodies stick to the HIV structure, and the data for the base structure for an AIDS vaccine starts in your CPU, you'll have your own special footnote in history.

"History was made today as an ugly spotty 16 year old metalhead discovered a key weakness in the human immunodeficiency virus. While he was dreaming about buying a better set of pickups and getting band groupies, his computer found an area on the virus where certain amino acids, when enzymatically bonded, would cause the body would generate normal antibodies and neutralise the virus. A vaccine is a few years away, but the discovery has the potential to save several million lives and all but eradicate AIDS from the planet. The metalhead, known only as "666slipkn0tkarnag3" could not be reached for comment but it is widely believed that somewhere he is playing power chords, chronically masturbating and unaware of the fact that he saved an entire generation of Africans."

But seriously... get the software and help. It's good for the soul.


Anyone who hasn't seen this thread, well, see it now.

There are almost no good things you can do that are easy, effortless and entirely free. But this is one of them.
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far_beyond_sane - contributing to the moral decay of your children since 1982

"It was some kind of evolutionary glitch, she figured; no different than the other unreasonable side effects of consciousness and emotion, like religion and rap music."
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  #90  
Old 2006-11-04, 09:46
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far_beyond_sane far_beyond_sane is offline
You gamma-minus fucktards
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An example of the difficulties and also the promise of this kind of research.
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far_beyond_sane - contributing to the moral decay of your children since 1982

"It was some kind of evolutionary glitch, she figured; no different than the other unreasonable side effects of consciousness and emotion, like religion and rap music."
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